Park began her musical career in 2006, featuring on singles released by labelmates Big Bang, Lexy, and Masta Wu. In 2009, she made her debut as a member of 2NE1 as the main vocalist. The group went on to become one of South Korea's most popular and best-selling girl groups of all time. Park has released two solo singles, "You and I" and "Don't Cry", which reached number one on the Gaon Digital Chart, the national music chart of South Korea. She was awarded Best Digital Single at the 2010 Mnet Asian Music Awards.
Following 2NE1's disbandment in 2016, Park left her group's agency, YG Entertainment, in November 2016. In July 2018, she signed with D-Nation Entertainment and released her comeback single, "Spring", in March 2019. After that, in May 2019, Park Bom released her new repackaged album re: Blue Rose, with the single "4:44" featuring Wheein from Mamamoo.